Antipyrine clearance and metabolite excretion in Saudi patients with non-alcoholic chronic liver disease

ABSTRACT

In this report, we examined the hepatic microsomal enzyme activity in 34 Saudi patients with chronic liver disease [CLD] and in 21 healthy Saudi subjects by measuring antipyrine clearance [APC1] and the fraction [%] of antipyrine [AP] dose excreted in urine unchanged [F[Ap] and in the form of its main metabolites 3-hydroxymethylantipyrine [F[HMAp]] norantipyrine [F[NORAP] and 4-hydroxyantipyrine [F[4OHAP]]- While APC1, F[HMAP] F[NORAP] and F[4OHAP] were significantly reduced in patients with CLD, F[AP] was significantly higher in these patients. Correlation was observed between serum albumin and APC1, F[HMAP] F[NORAP]'or F[4OHAP] and between each two of the last three variables. We conclude that Saudis with CLD have uniform rather than selective reduction of hepatic microsomal enzyme activity and that serum albumin is a sensitive indicator of this activity