Study of bile composition and antinucleating activity of bile in Egyptian patients with mixed gall stones

ABSTRACT

This study included two groups, one group of ten control subjects and a second group of ten patients suffering from mixed gall stones. The bile of all subjects was analyzed for glycoproteins, total bile acids, cholesterol, bicarbonate, total and ionized calcium, pH and antinucleating activity. The biochemical parameters studied except for bile acids were significantly increased in bile from patients with mixed gall stones as compared to normal bile. No statistical correlation was found between the decreased level of bile acids and the level of any of the studied parameters. The antinucleating activity of calculus bile was significantly decreased in those patients when compared to normal bile. It was concluded that calculus nucleation and growth is not caused by a single factor, but is mostly caused by a combination of multiple different factors whose roles are sharing in stone formation and in some way are connected. However, the relative role played by each factor in the nucleation and growth of stones can be deduced