Formulation and evaluation of piroxicam gels

ABSTRACT

The release of piroxicam from different gel bases viz., Pluronic F127, methyl cellulose [MC], Carbopol 934, hydroxypropyl methyl cellulose [HPMC], Eudispert [medium viscosity [mv]] was determined and compared with its release organogel bases which are mixtures of Eudragit L 100 or S100 with glycerol or propylene glycol. Results showed that Pluronic F127 and HPMC gels were the most efficient bases, while MC and organogel of Eudragit showed the least results. The effect of different enhancers viz., polysorbate 80, dimethylformamide [DMF] and lecithin on the release pattern of the drug from Eudispert [mv], Carbopol 934 and MC gel bases was also studied using different concentrations of the enhancers. It was found that polysorbate 80 was the most efficient enhancer at concentration 5% w/w of the base. The prepared piroxicam gel which showed the highest amount of drug released were applied on the rat hind paw previously injected with carrageenan and compared with oral and intraperitoneally [i.p.] formulae. It was found that there was a significant inhibition in edema volume in all groups of the dosed rates