Spectrophotometric investigation of meto-clopramide and promazine palladium II complexes

ABSTRACT

The color reaction of metoclopramide or promazine and palladium [II] chloride has been investigated. The optimum reaction conditions, spectral characteristics, conditional stability constants and composition of the water-soluble complexes have been established. The structure of palladium [II] chelates in the solid state is also studied. A spectrophotometric method is proposed for the determination of metoclopramide and promazine hydrochlorides in pure forms and in pharmaceutical preparations. The method is simple, reproducible and accurate and is easily applied to the determination in tables and injection solutions