Effect of dialysis on thyroid profile

ABSTRACT

Several parameters of thyroid function were estimated in 44 patients underwent hemodialysis and 8 patients underwent peritoneal dialysis, serum concentration of T4, T3, TSH, and T3RU Were measured before and after dialysis. The same measurements were performed, too, after 78hrs in 17 patients who were on hemodialysis. FT4I was calculated. T4 and FT4I was significantly increased after hemodialysis [5.9 +/- 1.9] [1.6 +/- 0.2] compared with the level before dialysis [5.1 +/- 1.3], [1.4 +/- 0.3], respectively. P<0.04, whole there was significant reduction in T3 after 68hr [0.5 +/- 0.3], P<0.04. Changes in other parameters were not significant. Apart from the subnormal levels of T3 before and after peritoneal dialysis, there was no significant change in any other parameters. We conclude that the increase in T4 after hemodialysis is likely due, in part, to the competitive binding exerted by heparin. And the relative long intervals between consecutive peritoneal dialysis caused a subnormal levels of T3