effect of flubendazole on the course of trichinella spiralis infection in mice: parasitological study

ABSTRACT

This work aimed to study the effect of flubendazole against different stages of Trichinella spiralis infection in mice. Three groups of experimental animals were examined Control group, group I [treated 3 days post-infection] and group II [treated 4 weeks post- infection]. In group I, flubendazole was shown to be a very potent agent in killing Trichinella spiralis adults and larvae, when given orally in a dose of 20 mg/kg for 5 consecutive days. This is evidenced by the significant reduction in number, length of the female and reproductive capacity as well as the absence of the muscle larvae. However, in group II, the effect of the drug although still significant yet diminished in all parameters as compared with the early treatment. These results evoked ideas for further design of other treatment and control of disease