Acute rheumatic fever another scope at immunological profile

ABSTRACT

Sero-immunological study was carried out on 111 patients with acute rheumatic fever [ARF] in comparison with patients' controls and normal group. Using streptococcal antibodies tests [antistreptolysin O [ASO], antistreptokinase [ASK] and antideoxyribonucleotidase B [ADNAseB tests]. Seropositivity for the antecedent streptococcal infection was raised from about 79.2% using the conventional antistreptolysin O [ASO] test to as high as 96.3% when two additional streptococcal antibody test was measured. In chorea patients ADNAse B was proved to be the only marker for the detectipn of the antecedent streptococcal infection. Mean serum ASO, ASK and ADNAse B titers in individual manifestation of ARF patients were studied