Selective histamine blockade in asthma: the effect of astemizole on resting bronchial tone and exercise induced broncho-constriction
Journal of the Faculty of Medicine-Baghdad. 1995; 37 (1): 51-59
em Inglês
| IMEMR
| ID: emr-37725
ABSTRACT
The orally active histamine HI-blocker astemizole was investigated for its effect on resting bronchial tone and exercise-induced broncho-constriction in 20 asthmatic patients by a double-blind placebo-controlled study. Astemizole produced acute bronchodilation with an average 16% improvement in FEVl by 3 hours. After exercise challenge, astemizole partially inhibited exercise induced bronchoconstriction. These results suggest that asthmatic patients have augmented background resting histamine tone which is reversible by Hl blockade
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Descanso
/
Asma
/
Asma Induzida por Exercício
/
Brônquios
/
Broncopatias
/
Astemizol
/
Constrição Patológica
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. Fac. Med.-Baghdad
Ano de publicação:
1995
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