Pattern of disaccharidases in chronic diarrhoea and malabsorption
Journal of the Faculty of Medicine-Baghdad. 1995; 37 (2): 275-285
em Inglês
| IMEMR
| ID: emr-37752
ABSTRACT
Disaccharide-splitting enzymes were analyzed in the jejunal mucosae of 48 patients suffering from chronic diarrhoea and/or malabsorption, and the results were compared to those of 11 controls. Four [36.4%] of the controls were found to have partial lactase deficiency with a mean ratio of sucrase to lactase activity of 54.8 [SEM +/- 60.06] Significant reduction in the disaccharidases [lactase, sucrase, maltase, and isomaltase] were observed in patients with celiac disease and primary intestinal lymphoma; other groups exhibited variable affection in all disaccharidasas. High incidence of hypolactasia in these patients is the net results of both genetic influence on lactase activity and as a consequence to mucosal injury. It is suggested that further studies should be carried out using intestinal biopsy and direct enzyme assay in a large number of healthy adults
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Sacarase
/
Doença Crônica
/
Beta-Galactosidase
/
Diarreia
/
Alfa-Glucosidases
/
Jejuno
/
Síndromes de Malabsorção
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. Fac. Med.-Baghdad
Ano de publicação:
1995
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