Comparative study between enoximone and dobutamine in post cardiopulmonary bypass in paediatric patients

The hemodynamic effects of either enoximone or dobutamine was studied in twenty pediatric patients randomly allocated in two equal groups that failed to come off bypass following open heart surgery. It was concluded that both enoximone and dobutamine produced favorable cardiovascular prefiles. There were no significant cardiovascular complications in any of either group of 10 patients each. Both enoximone and dobutamine increase mean CI by 26% [p <0.001] and 27% [p <0.001] respectively. They also decreased SVR by 11% [p <0.02] and 9% [p <0.01] respectively. The mean HR increased by 4.6% with enoximone and 19% with dobutamine. Urine output was satisfactory in both groups but was larger in volume in the enoximone group than in dobutamine group in which 2 patients needed frusemide to help urine output