Comparative antimicrobial activity of three quinolones, tetracyclines, doxycycline and minocycline against mycoplasma pneumoniae, mycoplasma hominis and ureaplasma urealyticum

ABSTRACT

Agar dilution technique was used to compare the antimicrobial activites of temafloxacin, sparfloxacin, ofloxacin, tetracycline, doxycycline and minocycline against 69 isolates of M. pneumoniae, 47 isolates of M. hominis and 38 isolates of U. urealyticum. Among the three quinolones agents tested, sparfloxacin was the most active agent against all the isolates. Doxycylcine has better activity than tetracycline against all the isolates. U. urealyticum were highly susceptible to minocycline and sparfloxacin with MIC90 of 0.35 micro g/ml and respectively. Among the six antibiotics tested the most active agent was sparfloxacin against M. pneumoniae and M. hominis and minocycline against U. urealyticum. Tetracycline and ofloxacin were the least active agents against all the isolates