Cyclic nucleotide phosphodiesterase in atopic patients

ABSTRACT

Phosphodiesterases share with adenylate cyclase the control of intracellular camp level. Cyclic AMP effects in the cells are mediated via camp dependent protein kinase [A kinase]. Therefore, it is expected that control of intracellular camp levels and hence, PDE activation would be predicted on the prequirements for A kinase activation. To evaluate the role of PDE in the atiopathogenesis of AD, 36 patients had been tested for PDE activity is isolated MNL reparation verus fifteen normal age and sex matched normal volunteers. The results data showed that camp specific PED activity in atopic MNL is consistently and significantly elevated compared to normal persons. Also, there is a strong correlation between the severity of the lesions and PED activity which was found to be increased in all phases of AD. These results certainly raise the possibility that elevated PDE activity may reflect a primary biochemical abnormality in AD