Perinatal predictive value of plasma plasminogen activator inhibitor and protein S versus other biophysical and laboratory tests in preeclampsia

ABSTRACT

This study was undertaken upon 30 preeclamptic women and 20 healthy gestational age matched controls to compare the ability of measuring plasma phasminogen activator inhibitor [PAI] and protein "S" [PS] concentrtaion to predict fetal and/or perinatal outcome. For comparison the same group underwent evaluation by well known tests of well proven predictive power, like BPS, NST, serum uric acid concentrations and hematocrite value. The study indicated that plasma PAI insignificantly higher in preeclamptic group compared to controls and plasma PS concentrations are significantly lower. However, putting a cut off levels at +/- 2 SD [standard deviation] from the mean values for controls resulted in a sensitivity and specificity in predicting fetal outcome which is less than satisfactory and not comparable to that obtained when biophysical score [BPS], NST or other biochemical tests were applied. In conclusion, wider scale studies are needed before reaching a final conclusion about the value of measuring PAI and PS in predicting fetal outcome in preeclampsia