Portal tract changes nearby malignancy

ABSTRACT

More than 22% of undirected percutaneous liver needle biopsies that are performed in search of metastatic neoplasms yield false negative specimens. Failure of sampling is also, met with directed needle biopsy. However, histologic changes are often observed in the liver adjacent to space occupying lesions due to focal obstructor of bile and blood flow. These alterations were defined in 20 liver specimens, with metastatic and primary malignant neoplasms, and revealed a characteristic histologic triad consisting of proliferated and abnormal bile ductules, polymorphonuclear leucocytes in edematous portal tracts, and focal sinusoidal dilatation. The changes had been compared with histologic changes associated with major biliary obstruction with a significant frequency of variable [P <0.05]. Therefore, the observation of the histologic triad described here should lead to a continued search for space occupying tumor in the liver