Combined insulin and sulfonylurea therapy in obese patients with type II diabetes mellitus

ABSTRACT

Our subjected were 40 non-insulin dependent diabetics treated with insulin. None of them was considered to be under adequate glycaemic control. Their urinary and blood sugar were measured according to the following intervention [a] For 2 days patients were on diet control only, [b] For 3 days patients were given NPH insulin preparation [30 U. subcutaneously] before breakfast, [c] For another 3 days. glibenclamide was added [2.5 mg] before dinner combined with the already mentioned insulin, [d] In the last 2 days, placebo was given instead of insulin, [e] In the last 2 days, placebo was given instead of insulin and glibenclamide. Urinary testing for glucose was done 3 times daily. The results revealed that the addition of glibenclamide was associated with statistically significant fall of the mean fasting and post-prandial blood glucose. This was more significant in the fasting blood glucose. This improvement might be explained by increased endogenous insulin secretion and the extrapancreatic effect of sulfonylureas