Clinical pharmacokinetics of benzodiazepines

ABSTRACT

The present article summarizes the clinical pharmacokinetic properties of benzodiazepines. The goal is to better prescribe these compounds in the field of anxiety, sleep disorders and as anticonvulsive drugs. All pharmacokinetic parameters are overviewed absorption, blood protein binding distribution, metabolisation and half-lives. A new approach is tried to find relationship between brain concentrations and receptor bindings in the purpose of giving an explanation of their duration of effect