propos de 211 cas de tumeurs hypophysaires pathogenie, classification et revue de quelques aspects cliniques

ABSTRACT

Pituitary tumors are frequently encountered and represent 10 to 15% of all intracranial tumors. Many new recent findings are changing their classical clinical, radiological and therapeutic picture. The role of different genes is giving us more insight into the pathogenesis of tumorigenesis such as the genes controlling cellular multiplication [MTS 1, p 53, nm 23,.] or the genes regulating the aging of the cell or its transformation into a malignant one. We have observed in a 12 period 211 cases of pituitary tumors. Prolactin producing tumors represented 58,8% of the total [124 cases], while we had 33 cases of Acromegaly [15,6%] and 19 cases of ACTH producing tumors [9,0%]. The 35 remaining cases classified as "non secreting tumors". The classification and the differential diagnosis of pituitary tumors are reviewed and some of our index cases are presented