relation between schistosomiasis and chronic carrier state in Salmonellosis: an experimental study

ABSTRACT

Experimentally-infected mice by schistosomal cercariae were also infected by S. paratyphi A to study the inter-relationship during the various stages of development as well as the role of adult worm in producing the carrier state. Cultures of the heartblood, liver, spleen and cuticle of adult worm were done. Immunofluorescent frozen sections of liver, spleen and adult worm were performed. The results showed that whereas schistosomules are not responsible of any prolonged bacteraemia; yet, from the fourth week onwords the ingestion of host-blood leads to prolonged bacteraemia. Specific reaction to S. paratyphi A was detected on the cuticle and caeca of adult worms up to the eight week of Salmonella infection. The liver and spleen also showed non-specific fluorescent reaction. Schistosomiasis leads to prolonged bacteraemia and state of chronic S. paratyphi A carriers by exhausting the R.E.S. of the individual