Non-steroidal anti-inflammatory agents: synthesis of pyrazolyl pyrazolinyl and pyrimidinyl derivatives of quinolone

ABSTRACT

Three novel series of quinoline derivatives have been prepared by cyclization of the intermediate, 3- [1-aryl-1-oxoprop-2-en-3-yl]-7-substituted-2-chloroquinolines [IIa-h], with hydrazine, phenylhydrazine or thiourea. The synthesized compounds were 3-[3-aryl-4,5-dihydro-1H-pyrazol-5-yl]-7-substituted 2-chloroquinolines [IIIa-h], 3[3-aryl-1-phenylpyrazol-5-yl] -7-substituted-2-chloroquinolines [IVa-h], and 4-aryl-6-[2-chloro-7 -substituted quinolin-3-yl]-5,6-dihydropyrimidine-2[3H]-thione [Va-h]. The antiinflammatory activity of representative examples of the prepared compounds was studied