Up-date insight into joint damage in rheumatoid arthritis study of serum and synovial fluid markers: soluble interleukin-2 receptor, hyaluronan, and alpha acid glycoprotein

ABSTRACT

This study aimed to measure serum and synovial fluid [SE] levels of soluble interleukin-2 receptor [sIL-2R], hyaluronic [hyaluronic acid, HA] and alpha-1 acid glycoprotein [AGP] in patients with rheumatoid arthritis and determined whether they correlated with clinical and laboratory parameters of disease activity and evaluate their values as specific markers for inflammation and joint damage. The sIL-2R levels were determined by ELISA, whereas serum and synovial fluid levels of both hyaluronan and AGP were determined by colorimetric methods. Twenty-five serum and eleven SF samples were obtained from patients with RA and twenty serum samples from age and sex matched controls. The results indicated that serum and synovial fluid of sIL-2R and HA might be more relevant markers of synovitis and inflammation. Their measurements in RA patients is useful in assessing disease activity, while serum and synovial fluid levels of AGP is considered as a useful marker in early rheumatoid arthritis