study on age changes in the cartilages of albino rats using protein S-100 antibody

ABSTRACT

Postnatal samples of the knee joints of different ages of albino rats were taken and fixed by formalin. Specimens were decalcified and exposed to peroxidase anti-peroxidase immunohistochemical technique using S-100 protein as an antibody. In young ages, the chondrocytes were S-100 negative and in adult ages there was positive immunoreactivity in these cells. The positivity disappeared in the old ages, this means that immunoreaction to S-100 protein is localized to the adult normal chondrocytes of the inner core of the articular cartilages. The ageing changes in the cartilage led to disappearance of this positivity. Further investigation is recommended using antirheumatic drugs to show if this positivity returns to these cells with therapy