Suinin, an antibiotic produced by a mutant of stretomtyces nasri [Hashem and Diab]

ABSTRACT

Suinin, is an aromatic anti-Gram-positive antibiotic obtained from a nitrosoguanidine mutant of Streptomyces nasri. The antibiotic was purified as reddish needles [Ig/OL]. UV, 1R,H-NMR,[13C-]NMR and mass spectra were performed in addition to Cosy and APT tests. The chemical formula of suinin was found to C[31]H[37]NO[5]. A proposed structure for suinin is included. The MIC for suinin against Bacillus subtilis ATCC 6633 was 1.5mg/ml, 2.0mg/ml against both Sarcina lutea OSUCC 495 and Staphylococcus aureus OSUCC 209 and 2.5mg/ml against Staphylococcus aureus OSUCC.680. Also, the interaction of suinin with some representatives of the widely used antibiotics was investigated. The result of this investigation recommended suinin to be an acceptable synergizer for some -lactam antibiotics, most aminoglycosidic antibiotics and some miscellaneous as polymyxin B, chtoramphenicol, minocycline, fusidic acid and rifampicin