Synthesis of certain substituted quinolines as potential DNA complexing agents

ABSTRACT

Two series of 2,4,6-trisubstituted quinoline derivatives were prepared for potential DNA complexing activity. The first series comprises the preparation of 4-arylaminoquinoline derivatives 9-24 by amination of 4-chloroquinolines 5-8, while, the second series involves the preparation of the amide derivatives of cinchoninic acid 27-30 by amidation of 2-phenyl-4-cinchonoyl chloride 26. Three new compounds were tested for in vitor cytotoxic activity