Synthesis and biological evaluation of 1,2,4 triazole and 1,3,4-Oxa-and Thiadiazoles derivatives
Egyptian Journal of Pharmaceutical Sciences. 1996; 37 (1-6): 71-84
em Inglês
| IMEMR
| ID: emr-40781
ABSTRACT
The alkaline hydrolysis with dimethylsulfate and potassium hydroxide of coumarin-6-derivatives [Ia-d] yielded 3-propenoic acid derivatives [IIa-d] which in turn were reached with thionyl chloride in toluene to give carbonyl chloride derivatives [IIa-d]. The latter compounds condensed with thiosemicarbazide in dioxane to give carbonylthiosemicarbazide derivatives [IVa-d], respectively. Cyclization of IVa-d, using sodium hydroxide yielded 5-mercapto- 1,2,4-triazol-3-yl-derivatives [Va-d]. Cyclodehydration of IVa-d using ortho-phosphoric acid or dicyclohexylcarbodiimide [DCC] led to the formation of the corresponding 5-amino-1,3,4-thia and oxadiazol-2-derivatives [VIa-d] and [VIIa-d], respectively. The antimicrobial and antiaflatoxigenic activities of Va-d, VIa-d were also evaluated
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Oxidiazóis
/
Cumarínicos
/
Aflatoxinas
/
Antibiose
Idioma:
Inglês
Revista:
Egypt. J. Pharm. Sci.
Ano de publicação:
1996
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