Synthesis and reactions of 2-chloromethyl-6-iodo-3, 1-benzoxazin-4-one with amines
Egyptian Journal of Chemistry. 1996; 39 (4): 387-93
em Inglês
| IMEMR
| ID: emr-40848
ABSTRACT
Certain quinazolinones were reported to exert antimicrobial activity[1]. Consequently, in continuation of our previous work on the reaction of 3,1-benzoxazin-4-ones with amines,[2-5], 2-chloromethyl-6- iodobenzoxazin-4-one was synthesized and allowed to react with amines hoping to obtain 4-quinazolinones for evaluation as antimicrobial agents. 5-Iodoanthranilic acid was chloroacetylated to give I which was cyclodehydrated to yield the corresponding 3,1-benzoxazin-4- one II Compound II was allowed to react with different aromatic amines to produce 3-aryl-2-chloromethyl-6-iodoquinazolin-4-ones IIIa-t. Structures of compounds III [Scheme 1] were confirmed by microanalytical and spectroscopic data [Table1 and 2]
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Oxazinas
/
Quinazolinas
/
Aminas
Idioma:
Inglês
Revista:
Egypt. J. Chem.
Ano de publicação:
1996
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