Effect of mammalian ambient temperature on leishmania major promastigotes: viability, morphology and immunogenicity in balb/c mice
IJMS-Iranian Journal of Medical Sciences. 1996; 21 (3-4): 125-129
em Inglês
| IMEMR
| ID: emr-41137
ABSTRACT
Change in temperature is one of the most important factors influencing the promastigote-to-amastigote transformation in Leishmania parasites. The present investigation studies the effect of mammalian temperature [37°C] on Leishmania major promastigote in regards to viability, morphology and immunogenicity in BALB/C mice. Temperature shifts from 25°C to 37°C in the studied Leishmania major strain induced incomplete transformation of the parasites, which included a shorter length and a thicker width, and reduced the parasite motility. The majority of parasites were alive 48 hours after the temperature shifts. With respect to their immunogenicity in BALB/C mice, the parasites transformed at 37°C did not differ significantly from those maintained at 25°C
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Temperatura
/
Leishmania major
/
Camundongos
Idioma:
Inglês
Revista:
Iran. J. Med. Sci.
Ano de publicação:
1996
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