Effects of propranolol and verapamil on glycerol-induced acute renal failure in mice

ABSTRACT

1. Several mechanisms have been suggested for the renal damage induced by intramuscular injection of glycerol. 2. We investigated the role of beta recetor desensitization by propranolol, and blocking calcium channels by verapamil in providing protection to the renal tissue from glycerol-induced acute renal failure. 3. Propranolol but not verapamil provided a significant protection reflected by lowering blood urea and serum creatinine and attenuating histopathological changes. 4. We conclude that acute renal failure induced by glycerol may be partly mediated by stimulation of renal beta receptor