Hepatitis E antibodies in Egyptian adolescent females: their prevalence and possible relevance
Journal of the Egyptian Public Health Association [The]. 1996; 71 (3-4): 273-284
em Inglês
| IMEMR
| ID: emr-41493
ABSTRACT
Hepatitis E virus has been implicated as a frequent cause of acute sporadic hepatitis among Egyptian children. Moreover, an extraordinarily high ear prevalence rate was previously reported in a semiurban Nile Delta population. A conspicuous feature of hepatitis E is the high morbidity and mortality it can cause among infected pregnant women. We therefore evaluated the prevalence of HEV antibodies in adolescent females using a solid-phase enzyme linked immunoassay based on two recombinant hepatitis E virus antigens. A high prevalence rate [38.9%] was found in 95 apparently healthy adolescent females. The mean age of the study subjects was 21.81 +/- 2.5 [SD] range 16-25 years. Eighty [84.2%] subjects resided in Alexandria, while 15 [15.8%] came from semiurban villages of Alexandria Governorate. An increased prevalence was noted with age, as anti-HEV antibodies were detected in 32.1% and 41.8% of study participants in the second and third decades of life, respectively, similarly, those illiterate or having received less than primary education exhibited a higher HEV prevalence than those with higher education [46.3% VS 29.3%]. The majority o subjects having serological evidence of HEV infection denied previous history of jaundice which shows that HEV infection was subclinical in those cases. Ten [55.6%] pregnant females participating in the study, as well as 48 [62.3%] non pregnant females lacked serological, evidence of HEV infection; i.e., 60.01% [10+48 out of 95] of women in the childbearing age may be susceptible to infection. This report suggests that HEV is endemic in Alexandria, Egypt; the epidemiologic risk factors associated with HEV infection need further exploration
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Prevalência
/
Adolescente
/
Vírus da Hepatite E
/
Anticorpos Antivirais
Tipo de estudo:
Estudo de prevalência
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
J. Egypt. Public Health Assoc.
Ano de publicação:
1996
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