Effects of prolactin on release and clearance of PMSG and HGG in rats

ABSTRACT

Administration of prolactin [2.5 i.u.] and antiprolactin serum [0.2 ml diluted antiprolactin serum, 13 in saline] twice daily for 5 days to study the relationship between both hormones and gonadotrophins resulted in 1- Prolactin increased pituitary HCG but not serum HCG-like activities. 2- Administration of prolactin to castrated rats increased serum HCG more than their controls, while their pituitary HCG remained unchanged in comparison with those intact treated ciontrol rats. 3- Injection of prolactin to Castrated rats decreased both pituitary and serum PMSG when compared with their castrated controls. 4- Administration of antiprolactin serum esulated in increased pituitary PMSG, but complete disappearance of pituitary and serum HCG. At the same time increased serum PMSG. 5- The clearance of PMSG in intact control rats was more rapid than HCG. This indicates that tflere is an initial uptake of PMSG followed by HCG. While prolactin inversed the above results. 6- Clearance of PMSG from the circulation was more rapid than HCG in the antiprolactin serum treated rats. 7- Anti-LTH serum caused rapid clearance of both serum HCG and PMSG. While prolactin decreased clearance of both serum HCG and PMSG