Comparative efficacies of macrolide antibiotics [erythromycin and roxithromycin] and cefadroxil in management of skin infections caused by staphylococcus aureus

ABSTRACT

The efficacy and safety of two macrolides [erythromycin and roxithromycin] and a B-lactam antibiotic [cefadroxil] were compared in management of skin and soft tissue infections caused by Staphylococcus aureus. A total of 55 cases were chosen including chronic recurrent cellulitis, furunculosis, ecthyma, pustular eruption infected burn, chronic leg ulcer and carbuncels. The mean duration of treatment was 7 days for roxithromycin therapy, 8.5 days for erythromycin therapy and 10.5 days for cefadroxil therapy. The clinical response rates were comparable for the three-treatment regimens