morpho-functional state of the brain under conditions of hypokinesia and its possible pharmacological correction by gaba-ergic substances

ABSTRACT

In this paper it has been shown that deterioration of the brain cortex capillary system and negative dynamics of cerebral tissue morphology occur under conditions of hypokinesia. Simultaneously, gamma-aminobutyric acid [GABA] and piracetam have been shown to favor the development of vasodilation and prevent further worsening of the cerebral blood supply. During the experiment, it was also established that among the substances investigated, the specific antagonist of GABA-receptors-bicuculline-displays the strongest cerebroprotective effect in early hypokinesia