Alteration of T-lymphocyte subpopulations in subacute and chronic brucellosis

ABSTRACT

Human brucellosis is a major health problem in developing countries. A number of patients with human brucellosis do not recover from the acute stage of the disease and pass into the chronic form. Since the pathophysiology of this change is not well understood, we studied the T-cell subsets during the acute, subacute and chronic forms of human brucellosis. In this study we found alterations in T-lymphocyte subsets and in the CD[4]/CD[8] ratio in subacute and chronic brucellosis while no significant change was found in T-cell subsets in acute brucellosis. We believe that this alteration of T-cell subsets is important in the pathophysiology of brucellosis, but it is not clear whether brucella cause this change or a primary immunodysfunction in patients with a disturbance in T-Cell subset regulation prevents recovery from acute brucellosis and leads to the development of chronic brucellosis