Effect of some tranquilizers on cerebrospinal fluid [CSF] in dogs

ABSTRACT

The changes in CSF constituents in anaesthetized dogs after intravenous injection of a single therapeutic dose of chlorpomazine propipnylpromazine or reserpine were studied over 3 hours, compared with corresponding values of the control and revealed that 1- Chlorpromazine in a dose of 1.0 mg/kg b.wt. significantly increased glucose level and inorganic phosphates in CSF but decreased urea nitrogen, sodium and chloride concentrations. No changes were observed in creatinine, potassium and calcium levels. 2- Propionylpromazine in a dose of 0.6 mg/kg b.wt. had no effect on all the studied parameters. 3- Reserpine in a dose of 0.5 mg/kg b.wt. significantly increased the glucose level for 3 hours and sodium concentration for one hour but decreased that of potassium during the whole period of the experiment. No changes occrurred in the concentrations of urea nitrogen, creatinine, chloride, calcium and inorganic phosphates