Systemic bioavailability of streptomycin sulphate and oxytetracycline hydrochloride in dogs

ABSTRACT

Evaluation of the pharmacokinetic properties of streptomycin [S] and oxytetracycline [O] were performed in dogs following a single i.m. and i.v. injection of therapeutic doses i.e. 10 mg and 3 mg/kg b.wt. respectively. The concentration of the antibiotics were determined by the microbiological assay method. The blood concentration curves following i.v. injection followed an open two compartment model. The highest concentrations of both drugs were reached after 40 min. following i.m. injection with corresponding t [0.5 alpha] values of 10.19 +/- 0.63 and 11.06 +/- 2.54 min., and t [0.5 beta] values of 6.05 +/- 0.22 and 6.27 +/- 0.36 hours respectively. The body clearance of [S] and [O] after i.v. injection showed close values i.e. 2.97 +/- 0.24 and 1.94 +/- 0.01 ml/kg [-1] min [-1] respectively. The systemic bioavailablitiy of the tested antibiotics after i.m. injection amounted to 83.29 +/- 2.61 and 83.82 +/- 3.60% respectively