Radiation therapy and chemotherapy in the treatment of rectosigmoid carcinomas
Medical Journal of Cairo University [The]. 1996; 64 (Supp. 3): 11-16
em Inglês
| IMEMR
| ID: emr-42314
ABSTRACT
Carcinomas of the rectum and sigmoid colon are the most common tumours of the gastrointestinal tract. The treatment results and prognostic factors of 63 patients with stage B-C carcinomas of the rectum and simoid colon were analyzed. Thirty-one patients [49%] had stage B disease. Thirty-two patients [51%] had stage C disease. All patients had surgical resection in the form of abdomino-perineal resction, anterior resection of rectal carcinoma, or simoid colon resection. This was followed by adjuvant treatment by external beam radiation therapy [dose of 4500-5040 cGy, at 180 cGy per fraction, five fraction a week] Using Six linear accelerator, adjuvant chemotherapy was given using fluorouracil and Leucovorin, for six months. The 3-year disease free survival for the whole group was 65%. Disease free survival rate at 3 years for stage B was 74% and for stage C, was 56%. The 56% local regional recurrence rate and distant metastasis rate at 3 years for the whole group was 35%. Distant metastases rate was 30%. No life threatening complications were recorded to this multidisciplinary treatment. The stage of the disease was the most important prognostic factor in predicting the survival
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Radioterapia
/
Resultado do Tratamento
/
Quimioterapia Adjuvante
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Med. J. Cairo Univ.
Ano de publicação:
1996
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