Predicting offensive-defensive potentials of an anticalmodulin versus Ca entry blockers on respiratory airways. an experimental study in non-sensitized and sensitized dogs

ABSTRACT

The experimental design comprised equally dividing 48 dogs into major groups A non-sensitized and a sensitized [by becoming positive for Ascaris lumbricoids antigen extract]. Required estimates were conducted on day 28 in both groups, but after being antigenically challenged only in the sensitized subgroups. In the non-sensitized series, results revealed that calcium entry blockers [CEBs] increased significantly enzymatic antioxidant activities in tracheal mucosa. A concomitant significant decrease in neutrophil phagocytic function was encountered by all drugs and in total leukocytic count by trifluoperazine [TFP] > verapamil hydrochloride [V] in comparison to control [C]. While, in the sensitized series, leukocytosis observed in sensitized [S] did not revert to normal by any of the studied drugs when all were compared to [C]. The concomitant blood and tracheal histamine were significantly reduced by [S + TFP] > [S + V] and only little affected by [S + N], while the significant hypocapnia and alkalosis encountered in [S] reverted to normal by CEBs when data were compared to [C]