Role of angiotensin II in pathogenesis of left ventricular hypertrophy [LVH] and microalbuminuria in essential hypertension

ABSTRACT

This study included 20 patients with essential hypertension and concomitant LVH, all were not receiving any medications before. They were assessed by M-mode echocardiography for assessment diagnosis of LV mass index. All patients were given 20 mg enalapril for 6 months and BP, LV mass index, microalbuminuria were assessed before and after treatment. There was significant drop of systolic and diastolic BP and regression of LV mass index with concomitant decrease in microalbuminuria. Systolic and diastolic BP were significantly correlated with LV mass index after treatment, while only diastolic BP was significantly correlated with microalbuminuria after treatment. These findings may point to role of angiotensin II in pathogenesis of LVH in essential hypertension