Effect of subcutaneous injection of mono-sodium glutamate on some nutritional and biochemical traits in albino rats

ABSTRACT

Mono-sodium glutamate [MSG] was administered sub-cutaneously to female rats 113.4 +/- 1.97 g body weight, as a food flavors at doses of 0.4, 0.8 and 1.2 mg per g body weight for 6-week period. MSG were significantly decreased body weight [26.5, 31.04 and 31.61%] and significantly increased feed consumption [22.92, 32.18 and 32.61%] and efficiency of feed utilization [60.44, 70.25 and 73.2%] for treated groups, respectively. No significant changes in weight of ovaries and spleen were shown. On the other h and, adrenal glands were significantly decreased, but weight of brain, heart, uterus, kidney, and liver were significantly increased in rats treated with MSG. Levels of blood glucose, urea, ceratinine, cholesterol, total protein, alkaline phosphatase, AST, and ALT were significantly increased in rat groups received MSG, while serum albumin was increased [nonsignificantly]. In conclusion, MSG may have a direct effect on functions of kidneys, liver and may inter adversely in carbohydrates, lipids, and proteins metabolism