Effects of cimetidine, ranitidine and tiotidine on spermatogenesis in albino rats

ABSTRACT

The effects of cimetidine, ranitidine and tiotidine were studied on spermatogenesis in adult male albino rats after administering these drugs at the dose levels of 5.71 mg/ kg, 2.14 mg/kg and 1.42 mg/kg body weight respectively twice daily for a period of five weeks. The results showed that cimetidine and tiotidine caused a significant decrease [P < 0.05] in the number of spermatocytes. However cimetidine and tiotidine produced a marked decrease [P < 0.05] and [P < 0.001] respectively, in the number of total germ cells in the seminiferous tubules. It is conceivable that ranitidine also possess antispermatogenic activity which was not found out in previous research work