Randomized, comparative, study of 1% Naftifine cream [once daily] and 1% Tioconazole cream [twice daily] in the treatment of Tinea cruris Naftifine cream [once daily] and 1% Tioconazole cream [twice daily] in the treatment of Tinea cruris

ABSTRACT

To compare the efficacy and tolerability of 1% naftifine cream [once daily] and 1% tioconazole cream [twice daily] in the treatment of tinea cruris. A randomized, comparative study of 4-week treatment followed by 4-week of wash-out period. Out-patient Clinic of Department of Dermatology, Mayo Hospital, Lahore. Thirty-three adult patients of either sex or age suffering from tinea cruis. Efficacy i.e. response to treatment in terms of clinical improvement and negative mycology and safety i.e. adverse effects. Of 33 evaluable patients, 15 patients were treated with naftifine cream and 18 with tioconazole cream. Isolated pathogens included, Trichophyton rubrum [n=16], Epidermophyton floccosum [n=9], T. interdigitale [n=7] and T. violaceum [n=1]. Final evaluation at 8 weeks showed 100% efficacy in both the groups. both the drugs were well tolerated. Naftifine is equal to tioconazole in terms of efficacy and safety in the treatment of tinea cruris