Disposition kinetics of apramycin in goats

ABSTRACT

The disposition kinetics and milk and urine concentration of apramycin were estimated in six goats. Following intramuscular and intravenous injection of 20 mg/kg b. wt., blood milk and urine samples were collected at 5, 15, 30 minutes, 1, 2, 4, 6, 8, 10, 12 hours post injected. The collected samples were used for determination of apramycin concentration using the microbiological assay method. Following intramuscular injection of apramycin, the highest concentration in serum was recorded at 1 hour with t0.5 [ab] value f 47.78 minutes and t0.5 [beta] f 1.53 hours. The peak milk and urine concentration was reached at 4 hours. Following intravenous injection of apramycin it follows two-compartment model with t0.5 [alpha] 14.11 minutes and t0.5 [beta] 3.22 hours, vc 0.97 l/kg. The C1[B] was 1.668 ml/kg. The mean systemic bioavailability was 78.25%. The protein binding% of apramycin of serum and milk was 8.5% and 39.25%, respectively