Some alterations concomitant with prolonged administration of estrogen

ABSTRACT

The study was done for deeper underst and ing of adverse effects concomitant with repeated administration of estrogens. It was found that, prolonged treatment, particularly with high doses, leads to deleterious effects represented by immunosuppresion, alteration of cellular structure of different organs as well as deviation of hepatorenal performance. Cautious use of estrogenic agents to avoid their drastic effect is recommended