effect of long term administration of sublethal dose of carbaryl [sevin] on the stomach of adult albino rat

ABSTRACT

This study aimed to examine the effect of long term administration of sublethal dose of carbaryl [Sevin] on the stomach of adult albino rats. Forty adults male albino rats were used and divided into two equal groups The first group served as controls and the second group was used to show the effect of carbaryl on the stomach by giving 25 mg carbaryl orally/rat/day for three months. The stomach was dissected and prepared for light and electron microscopic examination. The mucosa of the treated rat showed degeneration of the gastric glands with marked monocytic cellular infiltration. Only some parietal cells persisted the effect of the drug and looked healthy by light microscopy. However, EM studies showed that the parietal cells which appeared healthy in light microscopy showed degenerative changes in the form of dilated endoplasmic reticulum, enlarged mitochondria with loss of their cristae and vacuolation of their cytoplasm and nuclei. It was concluded that carbaryl induces hazard effects on the stomach of albino rats in the form of degeneration of the mucosa and marked cellular infiltration