Anticonvulsant and hypnotic agents: novel thiobarbituric acid derivatives of 4 [3H] -quinazolines

ABSTRACT

5 novel series of 4[3H]-quinazolinone derivatives have been prepared 2-methyl/phenyl-3-[3-substituted-4,6-dioxo-2-thioxohexahydropyrimidin- 1-yl]-4[3H]-quinazolinones [IIIa]; 2-phenyl-3-[3-aryl-5-benzylidene- 4,6-dioxo-2-thioxohexahydropyrimidin-1-yl]-4[3H]-quinazolinones [IVa- c]; 3-aryl-2-[3-aryl,-4,6-dioxo-2-thioxohexahydropyrimidin-1-yl] -iminomethyl-4[3H]-quinazolinones [VIa-f]; 3-aryl-2-[3-aryl-5- benzylidene-4,6-dioxo-2-thioxohexahydropyrimidin-1-yl] iminomethyl-4- [3H]-quinazolinones [VIIa-f] and 3-aryl-2-[3-[3-aryl-4,6-dioxo-2-thioxohexahydropyrimidin-1-yl]-4-oxo- 1,3-thiazolidin-2-yl]-4[3-H]-quinazolinones [VIIIa-f]. Some products showed anticonvulsant and hypnotic activities when tested in mice