Cytotoxic bianthrone C-glycosides from asphodel's aestivum tubers

ABSTRACT

Aestivin and 10'-deoxyaestivin are new class of cytotoxic bianthrone C-glycosides that have been isolated from the ethyl acetate extract of tuberous roots A. aestivus Brot. On the basis of spectral and chemical evidences, their structures were established as 10-C-[beta-D- xylopyranosyl]-1, 1, 8, 8', 10, 10'-hexahydroxy-3, 3'-dimethyl-10, 7-bianthracene-9, 9'-dione, and 10', C-[beta-D-xylopyranosyl]-1, 1', 8, 8', 10-pentahydroxy-3, 3'-dimethyl-10, 7'-bianthracene-9, 9'-dione, respectively. In addition, chrysophanol, asphodelin and olamodin were isolated and identified. Biologically, aestivin and 10'-deoxyaestivin proved to possess potent cytotoxic activity against mouse P388 leukemia and V-79 cells