Clinical and biochemical evaluation of growth hormone/insulin like growth factor I axis in chronic renal failure

ABSTRACT

This study was conducted to determine the plasma levels of GH, IGF- I tumor necrosis factor-alpha [TNF-alpha], NO, hyaluronan and fibronectin in plasma of 40 patients with chronic renal failure [CRF] of various clinical causes at presentation and after dialysis. Their levels were correlated with degree of renal impairment and the type of underlying pathology. The study also included 15 healthy controls with comparable age. The study revealed insignificant change in GH levels, significant decrease of IGF-I and fibronectin associated with significant increase in TNF-alpha, NO and hyaluronan in patients with CRF compared with healthy controls