Do anticardiolipin antibodies predict therapeutic response of nephrotic syndrome children?

ABSTRACT

In this study, IgG and IgM anticardiolipin antibodies [aCL] were determined in 25 children with nephrotic syndrome [NS] showing different underlying kidney pathology. The study also included ten matched healthy children as controls. Significant higher levels of both IgG and IgM aCL were detected in NS patients compared with the controls. However, no relation was found between aCL levels and age, renal histological pattern or renal function. Unlike serum creatinine level, which appeared to have a predictive value for response to therapy, no association was detected between aCL level and therapeutic response of NS children