role of oxidative stress in Egyptian patients with zoonotic cutaneous leishmaniasis

ABSTRACT

Zoonotic cutaneous leishmaniasis [ZCL] is endemic in North Sinai Governorate. It is a parasitic disease in which the immune system is implicated in its pathogenesis. The erythrocyte lipid peroxidation [ELPO], erythrocyte reduced glutathione [ERGT], glutathione peroxidase [GTPo] and serum vitamin C [SVC] were estimated in 19 patients with ZCL and 16 controls. The ELPO and ERGT were significantly higher in the patient group, while the GTPo and SVC were relatively lower. These results showed that the oxidative stress has a role in active ZCL, probably induces the endogen anti-oxidant system. That is to say, the oxidant-anti-oxidant balance system changes to the oxidative side with marked increase of erythrocyte lipid peroxidation and erythrocyte reduced glutathione