Nephrotic syndrome in children at king hussien medical center

ABSTRACT

To document the clinical profile, including the response to steroid therapy, of patients with primary nephrotic syndrome and the histopathological findings in steroid non-responders. Patients and A retrospective review of 125 children diagnosed as having primary nephrotic syndrome at King Hussien Medical Center between 1982-1994. Documentation included response to steroid, relapse rate, and histopathological diagnosis of resistant cases. 85 males and 40 females aged 1.5-12 years with a median age of four years were reviewed, 96 patients [76.8%] went into remission and 29 were steroid-resistant [23.2%]. Among those who were steroid-resistant, eight had minimal change nephropathy [MCNS], 14 had membranoproliferative glomerulonephritis and seven had focal segmental sclerosis [FSGS]. 64.5% of steroid-sensitive patients had further relapses, and 10.5% became steroid resistant. The demographic features of our patients, response to steroid therapy, and subsequent course are similar to those reported by others