Lipids in biliary lithogenesis

ABSTRACT

Serum and biliary lipoproteins, total cholesterol [Tc] and triglycerides [TG] were measured in patients with gallstones and in those without gallstones. Serum and biliary LDLc, TG and Tc were significantly higher [P < 0.001] in cases having gall stones than those without stones while HDLc were low [P < 0.001] in those with stones. No difference was found in very low density lipoproteins [VLDLc] in the two groups. Present data showed that there is a statistically significant correlation of serum and biliary lipoproteins specifically LDLc and HDLc [r = +.67 and r = +.56]. This report shows that serum HDLc [67.42%] and LDLc [70.28%] play a more critical role in comparison to total cholesterol [59.43%] and triglyceride [57.15%] levels in the formation of gallstone